Nitric oxide for autoimmune and chronic disorders

nitric oxide inflammation copy

When it comes to autoimmune disease and other chronic health conditions, taming inflammation is the name of the game. This can be difficult because the body creates vicious cycles where inflammation keeps feeding more inflammation. This makes halting the progression of autoimmune disease and chronic health issues difficult…but not impossible.

However, we now know about nutritional ingredients that can boost anti-inflammatory efforts. These ingredients act on two inflammatory immune messengers called “nitrous oxide” and “IL-17.”

IL-17 is a pro-inflammatory immune cell that damages body tissue, such as the thyroid gland in autoimmune Hashimoto’s, the joints in rheumatoid arthritis, or the nerve sheaths in multiple sclerosis. IL-17 isn’t completely bad—it’s necessary to fight infection. But when the immune system becomes hyper zealous, IL-17 goes out of control and attacks the body it’s designed to protect.

IL-17 destroys tissue by activating a “inducible nitric oxide,” one of three forms of nitric oxide, a gas, involved in various processes in the body. Two other two forms of nitric oxide are beneficial and actually fight inflammation: endothelial nitric oxide and neuronal nitric oxide.

However, inducible nitric oxide is pro-inflammatory and damages body tissue under the orders of IL-17.

Therefore, one way we can stop the vicious cycle of inflammation is to dampen IL-17 and inducible nitric oxide. Luckily, there are nutritional compounds that help the body do this.

But first — perhaps you’ve heard of arginine to boost nitric oxide. Although arginine boosts the anti-inflammatory endothelial and neuronal nitric oxides, it also boosts inducible nitric oxide. So if you are fighting chronic inflammation, taking arginine may work against you.

It’s safer instead to take nutritional compounds that studies show support endothelial nitric oxide. These include:

  • Adenosine
  • Huperzine A
  • Vinpocetine
  • Alpha GPC
  • Xanthinol niacinate
  • L-acetylcarnitine

These compounds work synergistically taken together in an emulsified liquid form. Not only does boosting endothelial nitric oxide tame inflammation, it also helps repair and regenerate body tissue, promote blood flow, dissolve plaques, and dilate blood vessels. Start with small doses to gauge effects and tolerance. These compounds also support neuronal nitric oxide and thus the health of your brain and nervous system.

Exercise is another excellent way to boost beneficial nitric oxides. In fact, take these endothelial nitric oxide boosting compounds before getting your heart rate to maximum capacity for a few minutes first thing in the morning. This will optimize anti-inflammatory effects and support brain health.

You don’t have to exercise long — just a few minutes of raising your heart rate as high as you can has profound anti-inflammatory and brain supporting effects. Just be sure not to over train as that produces more inflammation. Also, how you get your heart rate up depends on your fitness level and abilities, so keep it safe and doable.

Other tools to tame inflammation include therapeutic doses of vitamin D3, omega 3 fatty acids, absorbable forms of glutathione  and therapeutic doses of emulsified resveratrol and curcumin. These compounds have been shown to dampen the the inflammatory vicious cycles associated with autoimmune and chronic disorders.

Of course, lifestyle and diet changes are vital too. This includes eliminating pro-inflammatory foods with the autoimmune diet and designing an inflammation-quenching lifestyle.

For help taming your chronic inflammation and autoimmune disorder, ask my office for advice.

Fasting 13+ hours reduces cancer and disease risk

fasting for better health

Extended fasting during the night fast may lower your risk of breast cancer or improve your prognosis. Fasting has also been shown to decrease the risk for other types of cancer, type 2 diabetes, and cardiovascular disease.

In the first study of its kind, researchers analyzed 11 years of data from non-diabetic breast cancer patients, with surprising results.

The women who fasted less than 13 hours per night showed a 36 percent increase in breast cancer recurrence compared to those who fasted for 13 or more hours per night.

In other words, going at least 13 hours between between dinner and breakfast is associated with a lower risk of cancer.

The study looked at daily sleep and dietary habits, serum blood sugar and inflammation markers (hemoglobin A1c and C-reactive protein), and the recurrence of cancer and breast tumors.

Longer fasting for better sleep and less disease risk

The study showed that each two-hour increase in fasting time made for longer nights of sleep. This is important not only because it helps people feel better, but also because it points to a healthier sleep-wake cycle, or circadian rhythm  An imbalanced circadian rhythm increases cancer risk, including breast cancer, along with numerous other chronic diseases.

Each two-hour increase in fasting time also reduced blood sugar and systemic inflammation, hence lowering the risk of diabetes and other diseases.

The longer nighttime fasters showed significantly lower levels of C-reactive protein (CRP), a protein made in the liver that increases with inflammation. Chronic inflammation leads to serious diseases, including heart disease, some forms of cancer, dementia, Alzheimer’s, and Parkinson’s disease.

Got low blood sugar or adrenal fatigue? Then a bedtime snack may be appropriate

While the new research makes a strong case for extended nighttime fasting, long fasts may be detrimental to those with low blood sugar or adrenal fatigue.

In these cases, allowing blood sugar to drop too low through fasting can cause a series of negative hormonal consequences that result in insomnia, mood issues, fatigue, and poor brain function.

If you wake up anxious at 3 or 4 a.m., you may be a victim of low blood sugar and need to eat a little protein to fall back asleep. Eating a little bit before bed can also help prevent those all-too-early wakeup calls. You also need to follow a diet during the day that stabilizes blood sugar.

Eating a healthy blood sugar diet over time may help you stabilize your blood sugar to the point that you can comfortably adopt the extended nighttime fast.

A simple, non-medical strategy for reducing cancer and disease risk

These findings suggest that simply extending the time between dinner and breakfast to at least 13 hours may be a simple, non-medical strategy to reduce the risk of breast cancer and chronic disease.

If you have questions or concerns about nighttime fasting, sleep habits, blood sugar balancing, or disease prevention, please contact my office.